Publications

2017

Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos.
Bardot E, Tzavaras N, Benson DL, Dubois NC.
J. Vis. Exp. 2017 Oct 12;(128):e56446. doi: 10.3791/56446

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.
Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagá
n JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R.
Cell. 2017 Oct 12;(171):1-15. doi: 10.1016/j.cell.2017.09.018

Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
Magadum ADing YHe LKim TVasudevarao MDLong QYang KWickramasinghe NRenikunta HVDubois NWeidinger GYang QEngel FB.
Cell Res. 2017 Aug;27(8):1002-1019. doi: 10.1038/cr.2017.84. Epub 2017 Jun 16.

Optimizing Cardiac Delivery of Modified mRNA.
Sultana N, Magadum A, Hadas Y, Kondrat J, Singh N, Youssef E, Calderon D, Chepurko E, Dubois N, Hajjar RJ, Zangi L.
Mol Ther. 2017 Apr 4. pii: S1525-0016(17)30114-4. doi: 10.1016/j.ymthe.2017.03.016.

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.
Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC.
Nat Commun. 2017 Feb 14;8:14428. doi: 10.1038/ncomms14428.

In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.
Wyatt CM, Dubois N.
Kidney Int. 2017 Feb;91(2):265-267. doi: 10.1016/j.kint.2016.12.003.

 

2016

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L.
Nat Med. 2016 Dec; 22(12):1421-1427. doi: 10.1038/nm.4220.

Probing Early Heart Development to Instruct Stem Cell Differentiation Strategies
Calderon D, Bardot E, Dubois N.
Dev Dyn. 2016 Dec;245(12):1130-1144. doi: 10.1002/dvdy.24441.

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
Cashman TJ, Josowitz R, Gelb BD, Li RA, Dubois NC, Costa KD.
J Vis Exp. 2016 Mar 1;(109):e53447. doi: 10.3791/53447.

2015

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO.
Nat Commun. 2015 Sep 25;6:8391. doi: 10.1038/ncomms9391.

2014

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression
Josowitz R, Lu J, Falce C, D’Souza SL, Wu M, Cohen N, Dubois NC, Zhao Y, Sobie EA, Fishman GI, Gelb BD.
PLoS One. 2014 Jul 10;9(7):e101316. doi: 10.1371/journal.pone.0101316. eCollection 2014.

2013

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues
Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW.
Proc Natl Acad Sci USA. 2013 Dec 3;110(49):E4698-707. doi: 10.1073/pnas.1311120110. Epub 2013 Nov 19.

Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells
El-Mounayri O, Mihic A, Shikatani EA, Gagliardi M, Steinbach SK, Dubois N, Dacosta R, Li RK, Keller G, Husain M.
Cardiovasc Res. 2013 Apr 1;98(1):125-35. doi: 10.1093/cvr/cvs357. Epub 2012 Dec 4.

2011

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells
Dubois NC, Craft AM, Sharma P, Elliott DA, Stanley EG, Elefanty AG, Gramolini A, Keller G.
Nat Biotechnol. 2011 Oct 23;29(11):1011-8. doi: 10.1038/nbt.2005.

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
Kattman SJ, Witty AD, Gagliardi M, Dubois NC, Niapour M, Hotta A, Ellis J, Keller G.
Cell Stem Cell. 2011 Feb 4;8(2):228-40. doi: 10.1016/j.stem.2010.12.008

2008

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR.
Nat Genet. 2008 Dec;40(12):1436-44. doi: 10.1038/ng.256. Epub 2008 Nov 16.

Placental rescue reveals a sole requirement for c-Myc in emryonic erythroblast survival and hematopoietic stem cell function
Dubois NC, Adolphe C, Ehninger A, Wang RA, Robertson EJ, Trumpp A.
Development. 2008 Aug;135(14):2455-65. doi: 10.1242/dev.022707. Epub 2008 Jun 11. 

2006

Skin epidermis lacking the c-Myc gene is resistent to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene
Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, Trumpp A.
Genes Dev. 2006 Aug 1;20(15):2024-9.

Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues
Dubois NC, Hofmann D, Kaloulis K, Bishop JM, Trumpp A.

Genesis. 2006 Aug;44(8):355-60.

2005

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium
Bettess MD, Dubois N, Murphy MJ, Dubey C, Roger C, Robine S, Trumpp A.
Mol Cell Biol. 2005 Sep;25(17):7868-78.

2002

The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation
Beer HD, Munding C, Dubois N, Mamie C, Hohl D, Werner S.
J Biol Chem. 2002 Jun 7;277(23):20740-9. Epub 2002 Mar 27.